Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model.
Identifieur interne : 007E37 ( Main/Exploration ); précédent : 007E36; suivant : 007E38Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model.
Auteurs : Preeti Bajpai [Inde] ; Satish Vedi ; Mohammad Owais ; Sharad K. Sharma ; Prabh N. Saxena ; Shailja Misra-BhattacharyaSource :
- Journal of drug targeting [ 1061-186X ] ; 2005.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Antibactériens (administration et posologie), Antibactériens (usage thérapeutique), Brugia malayi (), Femelle, Filariose lymphatique (traitement médicamenteux), Humains, Liposomes, Modèles animaux de maladie humaine, Rats, Tétracycline (administration et posologie), Tétracycline (usage thérapeutique), Wolbachia (), Wolbachia (pathogénicité).
- MESH :
- administration et posologie : Antibactériens, Tétracycline.
- pathogénicité : Wolbachia.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Antibactériens, Tétracycline.
- Administration par voie orale, Animaux, Brugia malayi, Femelle, Humains, Liposomes, Modèles animaux de maladie humaine, Rats, Wolbachia.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (therapeutic use), Brugia malayi (drug effects), Disease Models, Animal, Elephantiasis, Filarial (drug therapy), Female, Humans, Liposomes, Rats, Tetracycline (administration & dosage), Tetracycline (therapeutic use), Wolbachia (drug effects), Wolbachia (pathogenicity).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Tetracycline.
- chemical , therapeutic use : Anti-Bacterial Agents, Tetracycline.
- drug effects : Brugia malayi, Wolbachia.
- drug therapy : Elephantiasis, Filarial.
- pathogenicity : Wolbachia.
- Administration, Oral, Animals, Disease Models, Animal, Female, Humans, Liposomes, Rats.
Abstract
Wolbachia bacteria, being filarial parasite symbiont have been implicated in a variety of roles, including development, fecundity and the pathogenesis of the filarial infections. Among various strategies used in the treatment of experimental filariasis, the elimination of symbiont Wolbachia seem to offer an efficient means of curing the disease. The antiwolbachial property of tetracycline has been well worked out; however, treatment needs to be continued for a prolonged period of time to achieve complete elimination of Wolbachia from the filarial parasites and their subsequent killing. This results in acute toxicity, thus limiting its practical utility for clinical implementation. In order to increase efficacy of the antibiotic with minimal toxic manifestations, we developed liposomized formulation of the tetracycline. The liposomized tetracycline was found to be significantly more effective when compared to the free form of the drug. In contrast to the 90/120 days oral administration of the drug, the treatment schedule using the liposomized form of the drug was reduced to 12 alternate days with better efficacy of the treatment.
DOI: 10.1080/10611860500285439
PubMed: 16278157
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003B65
- to stream PubMed, to step Curation: 003B65
- to stream PubMed, to step Checkpoint: 003B65
- to stream Ncbi, to step Merge: 002011
- to stream Ncbi, to step Curation: 002011
- to stream Ncbi, to step Checkpoint: 002011
- to stream Main, to step Merge: 008036
- to stream Main, to step Curation: 007E37
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model.</title><author><name sortKey="Bajpai, Preeti" sort="Bajpai, Preeti" uniqKey="Bajpai P" first="Preeti" last="Bajpai">Preeti Bajpai</name><affiliation wicri:level="1"><nlm:affiliation>Central Drug Research Institute, Divisions of Parasitology, Lucknow, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Central Drug Research Institute, Divisions of Parasitology, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Vedi, Satish" sort="Vedi, Satish" uniqKey="Vedi S" first="Satish" last="Vedi">Satish Vedi</name></author><author><name sortKey="Owais, Mohammad" sort="Owais, Mohammad" uniqKey="Owais M" first="Mohammad" last="Owais">Mohammad Owais</name></author><author><name sortKey="Sharma, Sharad K" sort="Sharma, Sharad K" uniqKey="Sharma S" first="Sharad K" last="Sharma">Sharad K. Sharma</name></author><author><name sortKey="Saxena, Prabh N" sort="Saxena, Prabh N" uniqKey="Saxena P" first="Prabh N" last="Saxena">Prabh N. Saxena</name></author><author><name sortKey="Misra Bhattacharya, Shailja" sort="Misra Bhattacharya, Shailja" uniqKey="Misra Bhattacharya S" first="Shailja" last="Misra-Bhattacharya">Shailja Misra-Bhattacharya</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16278157</idno><idno type="pmid">16278157</idno><idno type="doi">10.1080/10611860500285439</idno><idno type="wicri:Area/PubMed/Corpus">003B65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B65</idno><idno type="wicri:Area/PubMed/Curation">003B65</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003B65</idno><idno type="wicri:Area/PubMed/Checkpoint">003B65</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003B65</idno><idno type="wicri:Area/Ncbi/Merge">002011</idno><idno type="wicri:Area/Ncbi/Curation">002011</idno><idno type="wicri:Area/Ncbi/Checkpoint">002011</idno><idno type="wicri:doubleKey">1061-186X:2005:Bajpai P:use:of:liposomized</idno><idno type="wicri:Area/Main/Merge">008036</idno><idno type="wicri:Area/Main/Curation">007E37</idno><idno type="wicri:Area/Main/Exploration">007E37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model.</title><author><name sortKey="Bajpai, Preeti" sort="Bajpai, Preeti" uniqKey="Bajpai P" first="Preeti" last="Bajpai">Preeti Bajpai</name><affiliation wicri:level="1"><nlm:affiliation>Central Drug Research Institute, Divisions of Parasitology, Lucknow, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Central Drug Research Institute, Divisions of Parasitology, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Vedi, Satish" sort="Vedi, Satish" uniqKey="Vedi S" first="Satish" last="Vedi">Satish Vedi</name></author><author><name sortKey="Owais, Mohammad" sort="Owais, Mohammad" uniqKey="Owais M" first="Mohammad" last="Owais">Mohammad Owais</name></author><author><name sortKey="Sharma, Sharad K" sort="Sharma, Sharad K" uniqKey="Sharma S" first="Sharad K" last="Sharma">Sharad K. Sharma</name></author><author><name sortKey="Saxena, Prabh N" sort="Saxena, Prabh N" uniqKey="Saxena P" first="Prabh N" last="Saxena">Prabh N. Saxena</name></author><author><name sortKey="Misra Bhattacharya, Shailja" sort="Misra Bhattacharya, Shailja" uniqKey="Misra Bhattacharya S" first="Shailja" last="Misra-Bhattacharya">Shailja Misra-Bhattacharya</name></author></analytic><series><title level="j">Journal of drug targeting</title><idno type="ISSN">1061-186X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Brugia malayi (drug effects)</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Humans</term><term>Liposomes</term><term>Rats</term><term>Tetracycline (administration & dosage)</term><term>Tetracycline (therapeutic use)</term><term>Wolbachia (drug effects)</term><term>Wolbachia (pathogenicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (usage thérapeutique)</term><term>Brugia malayi ()</term><term>Femelle</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Liposomes</term><term>Modèles animaux de maladie humaine</term><term>Rats</term><term>Tétracycline (administration et posologie)</term><term>Tétracycline (usage thérapeutique)</term><term>Wolbachia ()</term><term>Wolbachia (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Tetracycline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Tetracycline</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Tétracycline</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia malayi</term><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Wolbachia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term><term>Tétracycline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Liposomes</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Brugia malayi</term><term>Femelle</term><term>Humains</term><term>Liposomes</term><term>Modèles animaux de maladie humaine</term><term>Rats</term><term>Wolbachia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Wolbachia bacteria, being filarial parasite symbiont have been implicated in a variety of roles, including development, fecundity and the pathogenesis of the filarial infections. Among various strategies used in the treatment of experimental filariasis, the elimination of symbiont Wolbachia seem to offer an efficient means of curing the disease. The antiwolbachial property of tetracycline has been well worked out; however, treatment needs to be continued for a prolonged period of time to achieve complete elimination of Wolbachia from the filarial parasites and their subsequent killing. This results in acute toxicity, thus limiting its practical utility for clinical implementation. In order to increase efficacy of the antibiotic with minimal toxic manifestations, we developed liposomized formulation of the tetracycline. The liposomized tetracycline was found to be significantly more effective when compared to the free form of the drug. In contrast to the 90/120 days oral administration of the drug, the treatment schedule using the liposomized form of the drug was reduced to 12 alternate days with better efficacy of the treatment.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Misra Bhattacharya, Shailja" sort="Misra Bhattacharya, Shailja" uniqKey="Misra Bhattacharya S" first="Shailja" last="Misra-Bhattacharya">Shailja Misra-Bhattacharya</name><name sortKey="Owais, Mohammad" sort="Owais, Mohammad" uniqKey="Owais M" first="Mohammad" last="Owais">Mohammad Owais</name><name sortKey="Saxena, Prabh N" sort="Saxena, Prabh N" uniqKey="Saxena P" first="Prabh N" last="Saxena">Prabh N. Saxena</name><name sortKey="Sharma, Sharad K" sort="Sharma, Sharad K" uniqKey="Sharma S" first="Sharad K" last="Sharma">Sharad K. Sharma</name><name sortKey="Vedi, Satish" sort="Vedi, Satish" uniqKey="Vedi S" first="Satish" last="Vedi">Satish Vedi</name></noCountry><country name="Inde"><noRegion><name sortKey="Bajpai, Preeti" sort="Bajpai, Preeti" uniqKey="Bajpai P" first="Preeti" last="Bajpai">Preeti Bajpai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007E37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007E37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16278157
|texte= Use of liposomized tetracycline in elimination of Wolbachia endobacterium of human lymphatic filariid Brugia malayi in a rodent model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16278157" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |